How to survive a long car trip

Line the seats with a large bath towel or seat.
The sheet will protect the back seat and expedite cleanup later.

Leave early.
Start a long trip early, before dawn, to assure that the kids will be sleepy and will nap for the first few hours of the wide. If they awake at or near rush hour, pull over to avoid traffic and get a break from driving.

Bring along a few key items and only what you really need.
Essential includes may include snacks, games, creative toys, and passive entertainment devices.

Make frequent stops
Do not expect small children to sit still for more than an hour or two at a time. Make frequent rest stops to switch drivers, stretch, to throw a ball, run around, and use the bathroom. These stops also serve to fend off car sickness and keep the driver alert.